Seeding activity of skin misfolded tau as a biomarker for tauopathies
Overall, our study provides proof-of-concept that the skin tau-SAA can differentiate tauopathies from normal controls, suggesting that the seeding activity of misfolded tau in the skin could serve as a diagnostic biomarker for tauopathies.
Authors
- Wen‐Quan Zou (ORCID: https://orcid.org/0000-0001-8062-0370)
- Vincenzo Donadio (ORCID: https://orcid.org/0000-0002-1290-7318)
- Maria Gerasimenko (ORCID: https://orcid.org/0000-0002-6344-9900)
- Tricia Gilliland (ORCID: https://orcid.org/0000-0002-7042-6352)
- Ling Wu (ORCID: https://orcid.org/0000-0002-2072-1468)
- Rocco Liguori (ORCID: https://orcid.org/0000-0002-1815-1013)
- Bin Xu (ORCID: https://orcid.org/0000-0002-0490-9540)
- Steven A. Gunzler (ORCID: https://orcid.org/0000-0003-2635-9022)
- Syed Zahid Ali Shah (ORCID: https://orcid.org/0000-0002-9638-5800)
- Zerui Wang (ORCID: https://orcid.org/0000-0002-8219-1458)
- Yirong Yang
- Evalynn Lomax
Institutions
- North Carolina Central University (US)
- University Hospitals of Cleveland (US)
- Jiangxi Provincial Academy of Medical Sciences (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Institute of Neurological Sciences (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University School (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1186/s13024-024-00781-1
- Citations
- 21
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.86
Funders
- Michael J. Fox Foundation for Parkinson's Research
- Alzheimer's Association
- Weston Brain Institute
- BAND foundation
- National Institutes of Health
- National Institute on Aging