Estimating the causal effect of dexamethasone versus hydrocortisone on the neutrophil- lymphocyte ratio in critically ill COVID-19 patients from Tygerberg Hospital ICU using TMLE method
The effect of dexamethasone is not significantly different from that of hydrocortisone on NLR in critically ill COVID-19 patients admitted to ICU. This implies that the difference in effect on NLR between the two drugs is due to random chance. TMLE remains an outstanding approach for causal analysis of observational studies with the ability to be augmented with multiple prediction approaches.
Authors
- Tonya M. Esterhuizen (ORCID: https://orcid.org/0000-0002-8703-1664)
- Jacques Lukenze Tamuzi (ORCID: https://orcid.org/0000-0003-1070-1962)
- Peter S. Nyasulu (ORCID: https://orcid.org/0000-0003-2757-0663)
- Rhoderick Machekano (ORCID: https://orcid.org/0000-0002-3433-2551)
- Lovemore Nyasha Sigwadhi (ORCID: https://orcid.org/0000-0002-4491-0845)
- Ivan Nicholas Nkuhairwe
Institutions
- University of the Witwatersrand (ZA)
- Stellenbosch University (ZA)
- City of Cape Town (ZA)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1186/s12879-024-10112-w
- Citations
- 1
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- Universiteit Stellenbosch