Citrullination of tissue factor pathway inhibitor alpha by peptidylarginine deiminase 4 impairs its natural anticoagulant activity toward factors Xa and VIIa/tissue factor and reduces binding to its cofactor protein S
Citrullinated TFPI shows impaired natural anticoagulant activity. While anti-FXa activity is essentially absent, its anti-TF/FVIIa activity can still be enhanced by protein S. This enhancement is incomplete; however, protein S binding to citrullinated TFPI is impaired.
Authors
- Tilman M. Hackeng (ORCID: https://orcid.org/0000-0003-0142-0843)
- Freek G. Bouwman (ORCID: https://orcid.org/0000-0002-5582-1370)
- Dennis Suylen
- Bryan Bouwens
- Rory R. Koenen (ORCID: https://orcid.org/0000-0002-9955-9730)
- Stella Thomassen (ORCID: https://orcid.org/0000-0002-9686-6364)
- Elke Magdeleyns
Institutions
- Maastricht University (NL)
Publication Details
- Journal
- Journal of Thrombosis and Haemostasis
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1016/j.jtha.2024.11.009
- Citations
- 1
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.29
Funders
- Trombosestichting Nederland