Type 2 diabetes and colorectal cancer: genetic causality explored via Mendelian randomization
Our bidirectional MR study and meta-analysis provide evidence that T2D increases the risk of colorectal cancer. However, there is no evidence to support a reverse causal relationship. These findings highlight the importance of monitoring and managing T2D as part of CRC prevention strategies.
Authors
- Cheng‐Yu Lin (ORCID: https://orcid.org/0000-0002-7985-1611)
- Qiuhong Ke
- Linhua Zhao (ORCID: https://orcid.org/0000-0002-0362-7365)
- Rui Tang (ORCID: https://orcid.org/0000-0002-3161-801X)
- Zhisheng Chen (ORCID: https://orcid.org/0000-0002-0854-2547)
- Ying‐Ying Huang (ORCID: https://orcid.org/0000-0003-3066-6981)
- Lanlan Cai (ORCID: https://orcid.org/0000-0002-1084-2848)
- W.J. Huang
- Ling Cheng
- Yimin Xu (ORCID: https://orcid.org/0000-0002-0119-3890)
- Bin Lin (ORCID: https://orcid.org/0000-0003-0931-1393)
Institutions
- Southwest Medical University (CN)
- Putian University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1007/s12672-024-01621-w
- Citations
- 2
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.10