Role of the GH-IGF Axis in Statural Growth and Harmonious Body Proportionality: In Search of Vitruvian Man?
These findings indicate that individuals homozygous for the GHR mutation have disharmonious body proportions due to abnormal GH/IGF-I action on the growth of the long bones. Contrary to common assumptions, disruption of the GH-IGF axis results in disproportionality and disharmonious growth.
Authors
- Ron G. Rosenfeld (ORCID: https://orcid.org/0000-0002-4030-5998)
- Enrique Terán (ORCID: https://orcid.org/0000-0001-6979-5655)
- George M. Bright (ORCID: https://orcid.org/0000-0001-9290-8160)
- Alexandra Guevara
- Jaime Guevara‐Aguirre (ORCID: https://orcid.org/0000-0001-9298-6484)
- Jannette Saavedra
- Maria Tite
Institutions
- Oregon Health & Science University (US)
- Maastricht University (NL)
- Instituto de Altos Estudios Nacionales (EC)
- Department of Health (TW)
- Seabrook (US)
- Universidad San Francisco de Quito (EC)
- Stanford University (US)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1210/clinem/dgae835
- Citations
- 2
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.72