Glutamate concentrations and cognitive deficits in ultra-treatment-resistant schizophrenia: An exploratory and comparative 1H-MRS study
Participants with uTRS exhibited significant cognitive deficits compared to healthy controls, though no significant differences in OCC Glu levels were found. While no clear linear or quadratic relationships emerged, Glu explained a small portion of the variance in cognitive performance, indicating a more complex role for Glu in cognition that warrants further investigation.
Authors
- Jamie J Lopes (ORCID: https://orcid.org/0009-0007-8800-9753)
- Erica Neill (ORCID: https://orcid.org/0000-0002-6920-2159)
- David Jonathan Castle (ORCID: https://orcid.org/0000-0002-3075-1580)
- Denny Meyer (ORCID: https://orcid.org/0000-0002-9902-0858)
- Susan Lee Rossell (ORCID: https://orcid.org/0000-0002-7415-8252)
- Caitlin Yolland (ORCID: https://orcid.org/0000-0002-1942-1492)
- Brian Dean (ORCID: https://orcid.org/0000-0001-7773-4473)
- Caroline Rae (ORCID: https://orcid.org/0000-0003-0673-8084)
Institutions
- University of Tasmania (AU)
- The University of Melbourne (AU)
- Florey Institute of Neuroscience and Mental Health (AU)
- St Vincent's Hospital Melbourne (AU)
- Orygen Youth Health (AU)
- Swinburne University of Technology (AU)
- Neuroscience Research Australia (AU)
Publication Details
- Journal
- Psychiatry Research Neuroimaging
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1016/j.pscychresns.2024.111926
- Citations
- 3
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.80