In silico prediction of the action of bromelain on PI3K/Akt signalling pathway to arrest nasopharyngeal cancer oncogenesis by targeting phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha protein
Our findings suggest that bromelain can target key proteins involved in NPC oncogenesis, with the strongest affinity towards PIK3CA. This suggests a hypothetical insight into bromelain's anticancer effects on NPC through the modulation of the PI3K/Akt signaling pathway.
Authors
- Alyaa Syafiqah Binti Shamsuri
- Edmund Ui‐Hang Sim (ORCID: https://orcid.org/0000-0001-8652-8495)
Institutions
- Universiti Malaysia Sarawak (MY)
Publication Details
- Journal
- BMC Research Notes
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1186/s13104-024-06995-2
- Citations
- 3
- Primary Topic
- Pineapple and bromelain studies
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Universiti Malaysia Sarawak