Zoonotic Potential of Chronic Wasting Disease After Adaptation in Intermediate Species
Chronic wasting disease (CWD) is an emerging disease in Europe. We report an increase in interspecies transmission capacity and zoonotic potential of a moose CWD isolate from Europe after passage in an ovine prion protein-expressing host. Those results indicated some CWD prions could acquire enhanced zoonotic properties following adaptation in an intermediate species.
Authors
- Jean‐Yves Douet (ORCID: https://orcid.org/0000-0002-0426-4957)
- Sylvie L. Benestad (ORCID: https://orcid.org/0000-0002-3011-0484)
- Tomás Barrio (ORCID: https://orcid.org/0000-0002-7037-6316)
- Juan María Torres (ORCID: https://orcid.org/0000-0003-0443-9232)
- Naïma Aron
- Alvina Huor
- Olivier Andréoletti (ORCID: https://orcid.org/0000-0002-7369-6016)
- Alicia Otero (ORCID: https://orcid.org/0000-0001-9075-2764)
- Rosa Bolea (ORCID: https://orcid.org/0000-0002-2746-3932)
- Hervé Cassard
- Juan Carlos Espinosa (ORCID: https://orcid.org/0000-0002-1643-2233)
- Séverine Lugan
Publication Details
- Journal
- Emerging infectious diseases
- Published
- 2024-11-29
- DOI
- https://doi.org/10.3201/eid3012.240536
- Citations
- 3
- Primary Topic
- Prion Diseases and Protein Misfolding
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- European Commission
- Agence Nationale de la Recherche
- HORIZON EUROPE Framework Programme
- Biotechnology and Biological Sciences Research Council
- European Regional Development Fund
- Interreg