Association of Striatal Dopamine Depletion and Brain Metabolism Changes With Motor and Cognitive Deficits in Patients With Parkinson Disease
Our findings suggest that in PD, striatal dopamine depletion and altered brain metabolism are closely linked, that changes in brain metabolism occur in specific spatial patterns depending on the degree of dopamine depletion, and that both differentially affect motor and cognitive dysfunction depending on each symptom.
Authors
- Sung Jun Ahn (ORCID: https://orcid.org/0000-0003-0075-2432)
- Chul Hyoung Lyoo (ORCID: https://orcid.org/0000-0003-2231-672X)
- Han Kyu Na (ORCID: https://orcid.org/0000-0002-2093-1641)
- Young Hoon Ryu (ORCID: https://orcid.org/0000-0002-9000-5563)
- Sung Woo Kang (ORCID: https://orcid.org/0000-0001-9791-6899)
- Han Soo Yoo (ORCID: https://orcid.org/0000-0001-7846-6271)
- Han‐Kyeol Kim (ORCID: https://orcid.org/0000-0002-7650-6708)
- Jae‐Hoon Lee (ORCID: https://orcid.org/0000-0002-9898-9886)
- Mina Park (ORCID: https://orcid.org/0000-0002-2005-7560)
Institutions
- Gangnam Severance Hospital (KR)
Publication Details
- Journal
- Neurology
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1212/wnl.0000000000210105
- Citations
- 4
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.48