Model-Based Scale-Up of a Homogeneously Catalyzed Sonogashira Coupling Reaction in a 3D Printed Continuous-Flow Reactor

The model-based scale-up of a homogeneously catalyzed Sonogashira coupling reaction is performed in a 3D printed metal continuous-flow reactor. The reaction is monitored with inline Raman spectroscopy with a low calibration effort, applying a multivariate curve resolution approach. Manufacturing conditions result in a space time yield of 412 kg m–3 h–1 and a productivity rate of 0.078 kg h–1.