Towards integrating imaging and immunology in glioblastoma: mapping blood immune system metrics to tumor magnetic resonance image data
We here provide first evidence that imaging and peripheral blood immunology features can go hand in hand and that imaging variables can correlate with systemic immunophenotypes. Especially a thick contrast-enhancing margin seems to indicate a pro-inflammatory immune state. Via pioneering the integration of imaging and immunology, we not only advance basic glioblastoma science but we also open up novel avenues for research. In the future, e.g. patient stratification for therapy development could be based on imaging-guided immunophenotyping.
Authors
- Carmen Visús
- Martha Nowosielski (ORCID: https://orcid.org/0000-0002-8068-315X)
- Johanna Heugenhauser (ORCID: https://orcid.org/0000-0001-5110-6663)
- Sarah Iglseder (ORCID: https://orcid.org/0000-0002-0912-7257)
- Georg Widhalm (ORCID: https://orcid.org/0000-0001-6014-0273)
- Thomas Felzmann
- Johanna Buchroithner
- Friedrich Erhart (ORCID: https://orcid.org/0000-0002-9708-3126)
- Christine Marosi
- Karl Rössler (ORCID: https://orcid.org/0000-0002-9249-8082)
Institutions
- Innsbruck Medical University (AT)
- Universität Innsbruck (AT)
- AOP Orphan (Austria) (AT)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Acta Neuropathologica Communications
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1186/s40478-024-01888-8
- Citations
- 1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.44