The antiviral activity of myricetin against pseudorabies virus through regulation of the type I interferon signaling pathway
PRV, belonging to the <i>Herpesviridae</i> family, is an easily overlooked zoonotic pathogen that can threaten human health. The immunoprotective efficacy of conventional vaccines is significantly reduced due to the continuous mutation of the PRV genome, which constantly generates new viral strains. Therefore, there is a need to develop potent therapeutic drugs. PRV is capable of evading the host's natural immunity by suppressing the host's type I interferon signaling pathway, and the search for drugs that activate natural immunity can induce the body to produce type I IFN interferon and exert antiviral effects. Accordingly, the present study sought to identify active compounds from flavonoids that modulate the type I IFN interferon signaling pathway and thus inhibit the proliferation of PRV, which provides a new idea for the development of anti-PRV drugs from flavonoids that modulate the type I IFN interferon signaling pathway to enhance the body's antiviral immunity.
Authors
- Yaqin Chen (ORCID: https://orcid.org/0009-0004-1806-8385)
- Yuanfeng Zou
- Xingyue Yu (ORCID: https://orcid.org/0000-0002-0210-8803)
- Y. Zhang (ORCID: https://orcid.org/0009-0003-7156-2799)
- Tao He (ORCID: https://orcid.org/0000-0002-1533-0761)
- Xu Song (ORCID: https://orcid.org/0000-0003-4102-0836)
- Xufan Zhao (ORCID: https://orcid.org/0000-0003-1128-7951)
- Yizhen Song
- Renyong Jia (ORCID: https://orcid.org/0000-0002-3539-9184)
- Zhongqiong Yin (ORCID: https://orcid.org/0000-0003-1752-644X)
- Xinghong Zhao (ORCID: https://orcid.org/0000-0003-2366-3360)
- Dongmei Zhang (ORCID: https://orcid.org/0000-0003-2497-3678)
- Mingyue Li (ORCID: https://orcid.org/0000-0001-5760-8429)
- Lixia Li (ORCID: https://orcid.org/0000-0002-7382-2190)
- Tianli Su
- Xun Zhou (ORCID: https://orcid.org/0000-0002-2000-1284)
- Juan Wang (ORCID: https://orcid.org/0000-0001-9452-7900)
Institutions
- Sichuan Agricultural University (CN)
Publication Details
- Journal
- Journal of Virology
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1128/jvi.01567-24
- Citations
- 6
- Primary Topic
- Herpesvirus Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.32
Funders
- China Agricultural Research System
- Natural Science Foundation of Sichuan Province
- Sichuan Veterinary Medicine and Drug Innovation Group of China Agricultural Research System
- Chengdu Science and Technology Program