Abietane Diterpenoids from the Rhizomes of <i>Kaempferia roscoeana</i> and Their Anti-Inflammatory Activities
Six new abietane diterpenes, roscoeananes A-F (<b>1</b>-<b>6</b>), along with two known compounds (<b>7</b>-<b>8</b>) were isolated from the rhizomes of <i>Kaempferia roscoeana</i>. The structures of all compounds were elucidated by analysis of spectroscopic data, and the absolute configurations were assigned by a comparison of the theoretical and experimental electronic circular dichroism (ECD) spectra and a comparison with literature values. The unreported compound <b>5</b> is an ether-linked dimer of roscoeanane B (<b>2</b>). Most of the isolated compounds were tested for their nitric oxide inhibitory effects in lipopolysaccharide-activated RAW264.7 cells. Among them, roscoeanane A (<b>1</b>) was found to reduce NO levels in murine macrophage cells with an IC<sub>50</sub> value of 3.58 ± 0.95 μM and exhibited low cytotoxicity (IC<sub>50</sub> > 50 μM).
Authors
- Apichart Suksamrarn (ORCID: https://orcid.org/0000-0001-8919-3555)
- Sareeya Bureekaew (ORCID: https://orcid.org/0000-0001-9302-2038)
- Lucksagoon Ganranoo (ORCID: https://orcid.org/0000-0002-4561-8504)
- Sarot Cheenpracha (ORCID: https://orcid.org/0000-0002-4333-1059)
- Chutamas Thepmalee (ORCID: https://orcid.org/0000-0002-3045-9539)
- Ratchanaporn Chokchaisiri (ORCID: https://orcid.org/0000-0003-4362-0050)
- Apinya Kaisoda
Institutions
- University of Phayao (TH)
- Department of Medical Sciences (RU)
- Center for Innovation (US)
- Vidyasirimedhi Institute of Science and Technology (TH)
- Ramkhamhaeng University (TH)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1021/acs.jnatprod.4c01127
- Citations
- 2
- Primary Topic
- Biological Activity of Diterpenoids and Biflavonoids
- Type
- article
- Field-Weighted Citation Impact
- 0.47