An immune suppressive tumor microenvironment in primary prostate cancer promotes tumor immune escape
In our cohort of prostate cancer patients who underwent radical prostatectomy, higher grade group and T-stage were independent predictors of BCR and metastasis. Despite higher grade group being associated with higher CD8+ cell density, PD-L1+ and PD-L1/CD8+ cell densities were low overall, suggesting lower T cell receptor recognition of tumor antigens. Further understanding of this phenomenon would influence development of future immunotherapeutic strategies in prostate cancer.
Authors
- Paul J. Neeson (ORCID: https://orcid.org/0000-0002-2729-5887)
- Anthony J. Costello (ORCID: https://orcid.org/0000-0003-3083-1799)
- Peter Gibbs (ORCID: https://orcid.org/0000-0003-1423-4484)
- Anthony J. Ryan (ORCID: https://orcid.org/0009-0006-0050-6417)
- Ryan Hutchinson (ORCID: https://orcid.org/0000-0001-8742-5236)
- Michael Christie (ORCID: https://orcid.org/0000-0001-8006-6832)
- A. Antón (ORCID: https://orcid.org/0000-0002-8459-7961)
- J. M. Peters
- Christopher M. Hovens (ORCID: https://orcid.org/0000-0002-0610-1289)
- Ben Tran (ORCID: https://orcid.org/0000-0002-8615-1314)
- Niall M. Corcoran (ORCID: https://orcid.org/0000-0003-4483-6945)
Institutions
- The Royal Melbourne Hospital (AU)
- The University of Melbourne (AU)
- Walter and Eliza Hall Institute of Medical Research (AU)
- Epworth Hospital (AU)
- Peter MacCallum Cancer Centre (AU)
- Western Health (AU)
- TissuPath (AU)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1371/journal.pone.0301943
- Citations
- 7
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.98