Synthesis of π-Extended Imidazo[1,2-<i>a</i>]quinolines via Carboxylic Acid-Assisted Ru(II)-Catalyzed Dual C–H Activation and Alkyne Annulation
Ru(II)-catalyzed, carboxylic acid-assisted oxidative annulation of <i>N</i>-aryl azoles with alkynes via double C-H activation to produce highly functionalized π-extended imidazo[1,2-<i>a</i>]quinolines is reported. The reaction features a broad substrate generality and tolerates various biologically relevant scaffolds. Interestingly, annulated products showed strong fluorescence properties and an AgIE effect and exhibited a selective fluorescent response toward the Cu<sup>2+</sup> ion. Further photocatalytic properties of the product are demonstrated in the photochemical coupling of azoles and arenes.
Authors
- Nitumoni Hazarika (ORCID: https://orcid.org/0009-0000-8336-1060)
- Monuranjan Konwar
- Animesh Das (ORCID: https://orcid.org/0000-0003-2178-7116)
Institutions
- Indian Institute of Technology Guwahati (IN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1021/acs.orglett.4c03522
- Citations
- 8
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 2.00
Funders
- Science and Engineering Research Board