Splenic T2 signal intensity loss on MRI is associated with disease burden in multiple myeloma
Question What changes occur in spleen signal on MRI as tumor load marker changes in multiple myeloma (MM)? Findings Spleen signal intensity, particularly on T2-weighted MRI, negatively correlates with bone marrow plasma cell infiltration and laboratory markers of tumor burden. Clinical relevance Standardized quantification of splenic T2 signal is proposed as a new marker for MM disease burden.
Authors
- Lukas John (ORCID: https://orcid.org/0000-0001-8178-6890)
- Antonia Dimitrakopoulou‐Strauss (ORCID: https://orcid.org/0000-0003-0338-9472)
- Felix Tobias Kurz (ORCID: https://orcid.org/0000-0001-7616-7147)
- Christos Sachpekidis (ORCID: https://orcid.org/0000-0001-8739-8741)
- Niels Weinhold (ORCID: https://orcid.org/0000-0002-5464-3234)
- Martin Grözinger
- Marc S. Raab (ORCID: https://orcid.org/0000-0003-4181-6922)
- Sandra Sauer (ORCID: https://orcid.org/0000-0001-5552-3149)
- Daniel Paech (ORCID: https://orcid.org/0000-0001-5755-6833)
- Peter Neher (ORCID: https://orcid.org/0000-0002-5285-7554)
- Markus Wennmann (ORCID: https://orcid.org/0000-0002-8092-8380)
- Elias Mai
- H Schlemmer
- Christian Neelsen (ORCID: https://orcid.org/0000-0002-1091-8179)
Institutions
- Brigham and Women's Hospital (US)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
Publication Details
- Journal
- European Radiology
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1007/s00330-024-11191-8
- Citations
- 2
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.91