Inhibition of IRE1α/XBP1 axis alleviates LPS-induced acute lung injury by suppressing TXNIP/NLRP3 inflammasome activation and ERK/p65 signaling pathway
In summary, our findings suggest that IRE1α-XBP1 axis is crucial in the pathogenesis of ALI/ARDS, whose suppression could mitigate the pulmonary inflammatory response and cell apoptosis in ALI through the TXNIP/NLRP3 inflammasome and ERK/p65 signaling pathway. Our study may provide new evidence that IRE1α-XBP1 may be a promising therapeutic target for ALI/ARDS.
Authors
- Yue Shen
- Lei Zhu (ORCID: https://orcid.org/0000-0001-6570-9123)
- Hanhan Liu (ORCID: https://orcid.org/0000-0001-9227-2588)
- Yi‐Peng Fu (ORCID: https://orcid.org/0000-0002-4229-6714)
- Fan Xu (ORCID: https://orcid.org/0000-0003-2968-6483)
- Lijuan Hu (ORCID: https://orcid.org/0000-0003-1968-0897)
- Sijiao Wang (ORCID: https://orcid.org/0000-0003-1380-3171)
Institutions
- Shanghai Jiao Tong University (CN)
- Peking University (CN)
- Fudan University (CN)
- Huadong Hospital (CN)
- Peking University People's Hospital (CN)
- Zhongshan Hospital (CN)
- Shanghai Sixth People's Hospital (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1186/s12931-024-03044-1
- Citations
- 5
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- Fudan University