Synthesis of 4-Hydroxy-5-phenylaminoimidazoles through a Three-Component Reaction of Sulfur Ylides, Nitrosobenzenes, and Amidines
A novel annulation reaction of amidines with sulfur ylides and nitrobenzenes has been developed, affording various novel 4-hydroxy-5-phenylaminoimidazoles in moderate to excellent yields. The 4-hydroxy-5-phenylaminoimidazoles have been further converted into α-ketoamide and imidazol-4-imine derivatives. Moreover, a plausible mechanism for this multicomponent reaction is proposed.
Authors
- Huajian Zhu (ORCID: https://orcid.org/0000-0002-6786-8811)
- Jiaan Shao (ORCID: https://orcid.org/0000-0001-8735-3236)
- Yifeng Hao (ORCID: https://orcid.org/0000-0001-9422-4686)
- Linghui Zeng (ORCID: https://orcid.org/0000-0002-3758-0366)
- Gongruixue Zeng
- Chaowei Xiang
- Yunlong Pan (ORCID: https://orcid.org/0000-0003-1211-469X)
- Jiankang Zhang (ORCID: https://orcid.org/0000-0003-0365-7238)
- Chong Zhang (ORCID: https://orcid.org/0000-0002-0780-6387)
Institutions
- Hangzhou City University
- Zhejiang University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1021/acs.joc.4c02079
- Citations
- 1
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.25
Funders
- Natural Science Foundation of Zhejiang Province