Chronic Traumatic Encephalopathy, Family History of Mental Illness, and Aggression in Brain Donors With Repetitive Head Impact Exposure
Among brain donors exposed to repetitive head impacts, CTE pathology moderated the effect of 1°FHMI on BGLHA scores, with the largest effects in midlife. Predisposition to mental illness and CTE pathology may increase risk of aggression beyond each risk factor's additive effects. Prospective studies are needed to confirm these results.
Authors
- Madeline Uretsky (ORCID: https://orcid.org/0000-0002-7604-3619)
- Douglas I. Katz (ORCID: https://orcid.org/0000-0002-7502-8505)
- Joseph Palmisano (ORCID: https://orcid.org/0000-0001-6000-3025)
- Neil W. Kowall (ORCID: https://orcid.org/0000-0002-6624-0213)
- Robert C. Cantu (ORCID: https://orcid.org/0009-0002-4300-4063)
- Thor D. Stein (ORCID: https://orcid.org/0000-0001-6954-4477)
- Danielle Rousseau
- Ann Carolyn McKee (ORCID: https://orcid.org/0000-0003-2961-7488)
- Zachary Baucom
- Shea Cronin
- Rebecca Burton
- Arsal Shah
- Lee E. Goldstein (ORCID: https://orcid.org/0000-0001-8419-9800)
- Evan Nair
- Nicole Saltiel (ORCID: https://orcid.org/0000-0003-0033-1814)
- Bobak Abdolmohammadi
- Bertrand R. Huber
- Michael L. Alosco (ORCID: https://orcid.org/0000-0002-8113-8428)
- Fatima Tuz‐Zahra (ORCID: https://orcid.org/0000-0003-1763-255X)
- John F. Crary (ORCID: https://orcid.org/0000-0002-0556-293X)
- Daniel H. Daneshvar (ORCID: https://orcid.org/0000-0003-3691-9513)
- Robert A. Stern (ORCID: https://orcid.org/0000-0002-5008-077X)
- Brigid Dwyer (ORCID: https://orcid.org/0000-0002-6446-8054)
- Shruti Durape
- Brett Martin
- Yorghos Tripodis (ORCID: https://orcid.org/0000-0003-2190-7608)
- Jonathan D. Cherry (ORCID: https://orcid.org/0000-0002-1257-981X)
- Jesse Mez (ORCID: https://orcid.org/0000-0003-1438-5442)
- Kristen Dams-O’Connor (ORCID: https://orcid.org/0000-0002-2506-0216)
- Victor E. Alvarez
Institutions
- Anna Needs Neuroblastoma Answers (US)
Publication Details
- Journal
- Neurology
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1212/wnl.0000000000210056
- Citations
- 2
- Primary Topic
- Traumatic Brain Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- U.S. Department of Defense
- U.S. Department of Veterans Affairs
- School of Medicine, Boston University
- National Institutes of Health
- Clinical and Translational Science Institute, Boston University