Temporal Dynamics of Plasma Neurofilament Light in Blood Donors With Preclinical Multiple Sclerosis
Patients with MS periodically sustain axonal injury up to 9 years before clinical onset, even in primary progressive disease. This most likely represents asymptomatic disease activity. Some or even all patients are affected by this intermittent axonal injury, prompting the need for further studies of the presymptomatic phase in relation to prognosis and as a therapeutic window of opportunity.
Authors
- Finn Thorup Sellebjerg (ORCID: https://orcid.org/0000-0002-1333-9623)
- Melinda Magyari (ORCID: https://orcid.org/0000-0002-0972-5222)
- Henrik Ullum (ORCID: https://orcid.org/0000-0001-7306-9058)
- Margit Hørup Larsen (ORCID: https://orcid.org/0000-0003-1679-5103)
- Anders Gorm Pedersen (ORCID: https://orcid.org/0000-0001-9650-8965)
- Susanne Rosthøj (ORCID: https://orcid.org/0000-0002-3619-413X)
- Ole Birger Pedersen (ORCID: https://orcid.org/0000-0003-2312-5976)
- Sisse Rye Ostrowski (ORCID: https://orcid.org/0000-0001-5288-3851)
- Bitten Aagaard (ORCID: https://orcid.org/0000-0001-8306-1332)
- Christian Erikstrup (ORCID: https://orcid.org/0000-0001-6551-6647)
- Josefine Britze
- Signe Modvig (ORCID: https://orcid.org/0000-0001-9113-1097)
- Helle Bach Søndergaard (ORCID: https://orcid.org/0000-0001-9435-0658)
- Jette Lautrup Frederiksen Battistini
Institutions
- Rigshospitalet (DK)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1212/nxi.0000000000200335
- Citations
- 11
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 3.01
Funders
- Jascha Fonden