Broad Analysis of Serum and Intrathecal Antimicrobial Antibodies in Multiple Sclerosis Underscores Unique Role of Epstein-Barr Virus
Despite the universal EBV seroprevalence, the frequency of intrathecally produced EBV antibodies in patients with MS is lower than that of other microbes, whose seroprevalences are lower than those of EBV. This seemingly paradoxical finding underscores the unique role of EBV in MS and could be explained by the hypothesis that B lineage cells responsible for intrathecal antibody production are primed during and through acute EBV infection to enter the CNS of patients with MS, that is, at a time point when EBV antibody-producing cells have not yet been generated and, therefore, are not yet available for entering the CNS.
Authors
- Brigitte Wildemann (ORCID: https://orcid.org/0000-0002-5389-3338)
- Katja Steinhagen
- Florence Pache (ORCID: https://orcid.org/0000-0003-2513-0664)
- Patrick Schindler (ORCID: https://orcid.org/0000-0002-8846-121X)
- Diana Wilken
- Klemens Ruprecht (ORCID: https://orcid.org/0000-0003-1962-6014)
- Evelin Grage‐Griebenow (ORCID: https://orcid.org/0009-0006-7159-3079)
- Tatjana Lietzow
- Carolin Otto (ORCID: https://orcid.org/0000-0002-9768-5143)
- Sven Jarius (ORCID: https://orcid.org/0000-0003-4849-2545)
- Moritz Niederschweiberer (ORCID: https://orcid.org/0000-0002-0234-1701)
Institutions
- Heidelberg University (DE)
- Humboldt-Universität zu Berlin (DE)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1212/nxi.0000000000200332
- Citations
- 2
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.85
Funders
- Guthy-Jackson Charitable Foundation
- Arthur Arnstein Stiftung
- European Commission
- Stiftung Charité