Obecabtagene Autoleucel in Adults with B-Cell Acute Lymphoblastic Leukemia

Obe-cel resulted in a high incidence of durable response among adults with relapsed or refractory B-cell ALL, with a low incidence of grade 3 or higher immune-related toxic effects. (Funded by Autolus Therapeutics; FELIX ClinicalTrials.gov number, NCT04404660.).

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Publication Details

Journal
New England Journal of Medicine
Published
2024-11-27
DOI
https://doi.org/10.1056/nejmoa2406526
Citations
159
Primary Topic
CAR-T cell therapy research
Type
article
Field-Weighted Citation Impact
44.92
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article

Obecabtagene Autoleucel in Adults with B-Cell Acute Lymphoblastic Leukemia

Jean A. Yared, Manuel Guerreiro, Kristen Marie O’Dwyer, Paul Shaughnessy et al.
159 citations
New England Journal of Medicine
CAR-T cell therapy research
44.92
article

Obecabtagene Autoleucel in Adults with B-Cell Acute Lymphoblastic Leukemia

Jean A. Yared, Manuel Guerreiro, Kristen Marie O’Dwyer, Paul Shaughnessy, Martha Arellano, Wolfram Brugger, Ram Malladi, Claire Roddie, Mehrdad Abedi, Martin Pulé, Bijal Shah, Luke Mountjoy, Amer Beitinjaneh, Pere Barba, Deborah Yallop, Pierre Lao‐Sirieix, Karamjeet Sandhu, Katharine Hodby, Eleni Tholouli, Aaron C. Logan, Jeremy Pantin, Tobias Menne, Armin Ghobadi, Michael R. Bishop, Yiyun Zhang, Jae H. Park, Daniel J. DeAngelo, Karl S. Peggs, Elias Jabbour, Sridhar Chaganti, Edgar Braendle
article en
159 citations

Abstract

Obe-cel resulted in a high incidence of durable response among adults with relapsed or refractory B-cell ALL, with a low incidence of grade 3 or higher immune-related toxic effects. (Funded by Autolus Therapeutics; FELIX ClinicalTrials.gov number, NCT04404660.).

New England Journal of MedicineVol. 391(23)
University College London Hospitals NHS Foundation Trust (GB), University Hospitals Bristol NHS Foundation Trust (GB), Newcastle upon Tyne Hospitals NHS Foundation Trust (GB), University College London (GB)
Zero hunger
Openalex Percentile: Top 0%
CAR-T cell therapy research
44.92
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