Obecabtagene Autoleucel in Adults with B-Cell Acute Lymphoblastic Leukemia
Obe-cel resulted in a high incidence of durable response among adults with relapsed or refractory B-cell ALL, with a low incidence of grade 3 or higher immune-related toxic effects. (Funded by Autolus Therapeutics; FELIX ClinicalTrials.gov number, NCT04404660.).
Authors
- Jean A. Yared (ORCID: https://orcid.org/0000-0002-5346-6299)
- Manuel Guerreiro (ORCID: https://orcid.org/0000-0001-5978-2578)
- Kristen Marie O’Dwyer (ORCID: https://orcid.org/0000-0001-8517-8198)
- Paul Shaughnessy (ORCID: https://orcid.org/0000-0003-4023-3864)
- Martha Arellano (ORCID: https://orcid.org/0000-0003-1636-1962)
- Wolfram Brugger
- Ram Malladi (ORCID: https://orcid.org/0000-0002-0242-630X)
- Claire Roddie (ORCID: https://orcid.org/0000-0002-4901-5858)
- Mehrdad Abedi (ORCID: https://orcid.org/0000-0003-4640-0977)
- Martin Pulé (ORCID: https://orcid.org/0000-0002-8347-9867)
- Bijal Shah (ORCID: https://orcid.org/0000-0003-4328-6021)
- Luke Mountjoy (ORCID: https://orcid.org/0000-0001-5140-8346)
- Amer Beitinjaneh (ORCID: https://orcid.org/0000-0002-1661-5865)
- Pere Barba (ORCID: https://orcid.org/0000-0001-7076-7969)
- Deborah Yallop
- Pierre Lao‐Sirieix
- Karamjeet Sandhu (ORCID: https://orcid.org/0000-0001-8024-8484)
- Katharine Hodby
- Eleni Tholouli
- Aaron C. Logan (ORCID: https://orcid.org/0000-0002-1179-5879)
- Jeremy Pantin (ORCID: https://orcid.org/0000-0001-7536-0623)
- Tobias Menne (ORCID: https://orcid.org/0000-0002-3289-2344)
- Armin Ghobadi (ORCID: https://orcid.org/0000-0001-8848-8474)
- Michael R. Bishop (ORCID: https://orcid.org/0000-0002-3979-9273)
- Yiyun Zhang (ORCID: https://orcid.org/0000-0003-4073-2663)
- Jae H. Park (ORCID: https://orcid.org/0000-0002-2903-5130)
- Daniel J. DeAngelo
- Karl S. Peggs
- Elias Jabbour
- Sridhar Chaganti
- Edgar Braendle
Institutions
- University College London Hospitals NHS Foundation Trust (GB)
- University Hospitals Bristol NHS Foundation Trust (GB)
- Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
- University College London (GB)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1056/nejmoa2406526
- Citations
- 159
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 44.92