Anti-tumor and anti-metastatic effects of RRx-001 on hepatocellular carcinoma: mechanisms of action and therapeutic potential
RRx-001 reduces the viability of HCC cells and induces apoptosis. This effect may be due to the downregulation of CD47 expression and the alteration of the TP53 protein regulatory pathway.
Authors
- Ziyan Lu (ORCID: https://orcid.org/0000-0003-2901-3801)
- Meifeng Chen (ORCID: https://orcid.org/0000-0002-7170-0843)
- Chuangye Han (ORCID: https://orcid.org/0000-0002-7670-4763)
- Shutian Mo (ORCID: https://orcid.org/0000-0001-9385-0757)
- Guohong Yan (ORCID: https://orcid.org/0000-0002-1978-9393)
- Shuxin Wei
- Jiaming Liang (ORCID: https://orcid.org/0000-0002-9807-2437)
- Xinping Ye (ORCID: https://orcid.org/0000-0002-9200-1312)
- Shuqi Zhao (ORCID: https://orcid.org/0009-0001-6297-5220)
- Yuan Liao (ORCID: https://orcid.org/0000-0003-2967-4845)
- Hailian Huang
Institutions
- Guangxi Medical University (CN)
- Nanyang Institute of Technology (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-11-27
- DOI
- https://doi.org/10.3389/fphar.2024.1469825
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangxi Province
- Guangxi Medical University
- Division of Graduate Education