Network Mendelian randomisation analysis deciphers protein pathways linking type 2 diabetes and gastrointestinal disease
The study identified some proteins mediating T2D-GI disease associations, which provided biological insights into the underlying pathways.
Authors
- Xuejie Chen (ORCID: https://orcid.org/0000-0001-8459-2557)
- Zhongyan Du (ORCID: https://orcid.org/0000-0002-0008-0712)
- Jie Chen (ORCID: https://orcid.org/0000-0002-4029-4192)
- Dipender Gill (ORCID: https://orcid.org/0000-0001-7312-7078)
- Jiawei Geng (ORCID: https://orcid.org/0000-0002-7622-2692)
- Shuai Yuan (ORCID: https://orcid.org/0000-0001-5055-5627)
- Xixian Ruan (ORCID: https://orcid.org/0000-0002-4937-9168)
- Stephen Burgess (ORCID: https://orcid.org/0000-0001-5365-8760)
- Susanna C. Larsson (ORCID: https://orcid.org/0000-0003-0118-0341)
- Xue Li (ORCID: https://orcid.org/0000-0002-4515-6792)
- Xing Wu (ORCID: https://orcid.org/0000-0002-1512-4984)
- Jonas F. Ludvigsson
- Tian Fu
Institutions
- Zhejiang Chinese Medical University (CN)
- Uppsala University (SE)
- Central South University (CN)
- University of Cambridge (GB)
- Columbia University Irving Medical Center (US)
- Karolinska Institutet (SE)
- Örebro University Hospital (SE)
- MRC Biostatistics Unit (GB)
- Third Xiangya Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Imperial College London (GB)
- University of Pennsylvania (US)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1111/dom.16087
- Citations
- 3
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.65
Funders
- Wellcome Trust
- UK Research and Innovation
- British Heart Foundation
- National Natural Science Foundation of China
- Cancerfonden
- Vetenskapsrådet
- Medical Research Council
- Science Fund for Distinguished Young Scholars of Zhejiang Province