Blood based immune biomarkers associated with clinical frailty scale in older patients with melanoma receiving checkpoint inhibitor immunotherapy
Several ageing and frailty associated changes were detected among circulating immune cells in blood but were not associated with response to immunotherapy in our study. While these findings suggest that the level of frailty and ageing may not necessarily preclude the efficacy of ICI therapy, further investigation is needed to fully understand the impact of frailty and ageing on immunotherapy.
Authors
- Johanneke E.A. Portielje (ORCID: https://orcid.org/0000-0002-5169-6306)
- Ellen Kapiteijn (ORCID: https://orcid.org/0000-0002-4814-6426)
- Saskia J. Santegoets (ORCID: https://orcid.org/0000-0002-2874-4402)
- Diana van Heemst (ORCID: https://orcid.org/0000-0001-8526-7748)
- Estelle Tran Van Hoi (ORCID: https://orcid.org/0000-0002-7325-7523)
- Sjoerd H. van der Burg (ORCID: https://orcid.org/0000-0002-6556-0354)
- Nienke A. de Glas (ORCID: https://orcid.org/0000-0001-8350-4252)
- Marije Slingerland (ORCID: https://orcid.org/0000-0002-4181-8656)
- Els M.E. Verdegaal (ORCID: https://orcid.org/0000-0002-4449-8707)
- Marij J.P. Welters (ORCID: https://orcid.org/0000-0002-9809-8266)
- Simon P. Mooijaart (ORCID: https://orcid.org/0000-0003-3106-3568)
- A. Özkan (ORCID: https://orcid.org/0000-0002-6729-9479)
Institutions
- Leiden University Medical Center (NL)
- Norsk Geografisk Selskap (NO)
- Oncode Institute (NL)
Publication Details
- Journal
- Immunity & Ageing
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1186/s12979-024-00463-y
- Citations
- 6
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 2.07