Estrogenized HSA induced high-affinity autoantibodies in breast cancer - Novel biomarker for early detection
Estrogenized HSA is highly immunogenic, resulting in functional alterations. High affinity antibodies were detected in BC patients against 4-OHE<sub>2</sub>-HSA. Consequently, 4-OHE<sub>2</sub>-HSA may serve as a novel molecular target for potential cancer therapeutics. Furthermore, autoantibodies against 4-OHE<sub>2</sub>-HSA could serve as a potential biomarker for early detection of BC.
Authors
- Wahid Ali Khan (ORCID: https://orcid.org/0000-0002-2561-9155)
- Khalid Al-Motair
- Subuhi Sherwani (ORCID: https://orcid.org/0000-0002-0631-708X)
- R. Saravanan (ORCID: https://orcid.org/0000-0002-4234-9417)
- Saheem Ahmad (ORCID: https://orcid.org/0000-0003-1215-0279)
- Hamda Khan (ORCID: https://orcid.org/0000-0003-2448-9878)
- Mohd Wajid Ali Khan (ORCID: https://orcid.org/0000-0001-9089-9176)
Institutions
- Aligarh Muslim University (IN)
- Integral University (IN)
- University of Ha'il (SA)
- King Khalid University (SA)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-11-27
- DOI
- https://doi.org/10.3389/fonc.2024.1493320
- Citations
- 1
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.40
Funders
- University of Hail