How do autoimmune CD4+ T cells handle exhaustion?
Chronic antigen exposure is frequently associated with T cell exhaustion. In a recent study, Aljobaily et al. show that pancreatic islet-infiltrating CD4<sup>+</sup> T cells in mouse autoimmune diabetes may circumvent exhaustion by preserving TCF1 expression. Continuous recruitment of epigenetically pre-programmed CD62L<sup>+</sup> CD4<sup>+</sup> T cells seems to sustain the local autoimmune response.
Authors
- Lucy S. K. Walker (ORCID: https://orcid.org/0000-0001-5986-5015)
- Astrid Fabri (ORCID: https://orcid.org/0000-0003-2233-1719)
Institutions
- Institute of Infection and Immunity (CA)
- University College London (GB)
Publication Details
- Journal
- Trends in Immunology
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1016/j.it.2024.11.004
- Citations
- 2
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.55
Funders
- Wellcome Trust
- Medical Research Council