Synthesis and biological evaluation of novel thiazole derivatives as anti-diabetic potential agents

Diabetes mellitus is considered as achronic disease causing oxidative stress that promotes tissue damage. The purpose of this work is to evaluate the antioxidant activity of new hydrazine thiazole derivatives in vitro, Considering the diverse array of biological activities exhibited by thiazole derivatives. A new series of hydrazine thiazole was prepared following the Hanztsch method. Physical characteristics (melting point) were used to initially validate each compounds. Afterwards, a variety of spectroscopic methods, including 1H, 13C-NMR, and mass spectrometry, confirmed these results. All components' binding interactions were investigated through the use of a molecular docking simulation technique. Additionally, the potential of each component in terms of α-glucosidase and antioxidants was assessed. All synthesized derivatives were approved biocompatible with blood glucose levels in diabetics compared to the standard acarbose. Among the examined components, compared to acarbose (IC50 = 0.597 ± 0.022 µM), analogue (3) (IC50 = 0.69 ± 0.025 µM) was discovered to be a highly potent contender against α-glucosidase. Docking studies further supported the antidiabetic potential. All of the synthesized components showed a variety of interactions along the active sites of the enzymes with varying binding energies, according to docking experiments.