The Role of Central Venous Oxygen Saturation as a Prognostic Factor for Intensive Care Unit-Admitted Aluminum Phosphide-Poisoned Patients

Background: Aluminum phosphide (ALP) is one of the most significant reasons of fatal poisoning globally. Many ALP-poisoned patients deteriorate even in high-level specialized hospitals with advanced life-support equipment & a known antidote do not exist. Objectives: This study aimed to focus on the role of central venous oxygen saturation as a prognostic factor in aluminum phosphide-poisoned patients. Patients and methods: A prospective study had been carried out on 84 AlP-poisoned cases who met the inclusion criteria. Clinical sheets had been created and contained data collection such as sociodemographic data, history and physical examination. Hemodynamic assessment, laboratory tests, left ventricular ejection fraction (LVEF%) by transthoracic echocardiography, and central venous oxygen saturation (ScvO2) were measured on admission, following six hours of therapy, following 24 hours, and on discharge or mortality and were compared between non-survivors and survivors. Results: A statistically significant variance had been detected among the groups under investigation in terms of LVEF% after 6 hrs, LVEF% after 24 hrs, LVEF% on discharge or death, ScvO2 after 6 hrs, ScvO2 after 24 hrs, and ScvO2 on discharge or death. Cutoff value of 50.5 LVEF% on admission had a sensitivity of 73% & specificity of 77% for predicting AlP-poisoned patients’ survival with a statistically significant difference. Cutoff value of 41.5 LVEF% after 6 hrs had a sensitivity of 80.5% and a specificity of 75% for expecting AlP-poisoned patients’ survival with a statistically significant difference. Cutoff value of 47.5 LVEF% after 24 hrs had a sensitivity of 80.5% & a specificity of 74.4% for expecting AlP-poisoned patients’ survival with a statistically significant difference. Cutoff value of 39 LVEF% on discharge or death had a sensitivity of 90.2% and specificity of 99% for expecting AlP-poisoned patients’ survival with a statistically significant difference. Conclusion: ScvO2 had a prognostic role for expecting of mortality in cases that had ALP poisoning.