Dental Mesenchymal Stem Cell Secretome: A Cell-free Therapeutic Approach for Tissue Regeneration

Dental mesenchymal stem cells (MSCs) have emerged as a promising therapeutic avenue for tissue regeneration in regenerative medicine. While cellular transplantation of MSCs has shown potential for achieving functional tissue regeneration, several clinical challenges hinder its implementation. An alternative approach, harnessing the secretome of MSCs, has gained attention as a cell-free therapeutic strategy. The secretome encompasses the bioactive molecules released by MSCs, which have been shown to exert profound effects on tissue regeneration. This review comprehensively analyzes the dental MSCs secretome, understanding the potential of the MSCs secretome, addressing the obstacles associated with its utilization, and its potential as a valuable resource for regenerative therapies. In summary, the secretome of dental MSCs holds great promise as a cell-free therapeutic strategy for tissue regeneration. This review highlights the importance of further research and standardization efforts to fully exploit the therapeutic potential of the MSCs secretome and realize its clinical translation in regenerative medicine.