EVALUATION OF SALVIA ROSMARINUS AND CORIANDRUM SATIVUM AS CHEMOPREVENTIVE AGENTS IN INDUCED ORAL SQUAMOUS CELL CARCINOMA (AN EXPERIMENTAL STUDY)

Introduction: The most prevalent malignant tumor of the head and neck region is squamous cell carcinoma. The bad prognosis and low survival rate are mainly related to oral cancer patients. Developing chemopreventive techniques has been crucial to reduce the incidence of oral cancer. Chemoprevention with natural products has emerged as viable preventive options. Salvia rosmarinus and Coriandrum sativum have been studied and discovered to have powerful anticancer properties. Aim of the study: The present trial was proceeded to study the effects of salvia rosmarinus and coriandrum sativum during experimental hamster buccal pouch carcinoma induction; using PCNA as cancer proliferative cell marker.Material and Methods: A total of 60 adult male hamsters were divided into 5 equal groups. Group I, biopsies of normal pouch mucosa were obtained as a negative control. All remaining groups were painted by DMBA as a carcinogenic agent. Group II, as a positive control group, was only painted by DMBA. Group III received topically salvia rosmarinus oil. Group IV received topically coriandrum sativum oil. Group V received both oils together. After 16, 24, and 32 weeks, 2 to 4 animals from every group had been sacrificed. Tissue lesions were prepared, and paraffin sections were stained with primary antibody for PCNA immunohistochemical evaluation.Results: The salvia rosmarinus and coriandrum sativum; either alone or in combination, significantly reduced the carcinogenic effect for DMBA-induced oral carcinogenesis. Conclusion: Salvia rosmarinus and coriandrum sativum have a chemopreventive considerable action versus oral cancer development, and their synergetic action is considerably more effective.