Toward Polymeric Room Temperature Acid Generators
Although a variety of acid-generating molecules have been developed, the formation of toxic byproducts and the need for light-activation or temperatures that may be incompatible with physiological conditions leave room for the optimization of biocompatible acid-generators. Herein, we report 4-hydroxybenzyl chloride derivatives that generate hydrochloric acid via hydrolysis at the benzylic position at room temperature in the absence of light. Utilizing the acetal protected 4-hydroxybenzyl chloride scaffold, we access a myriad of compounds that generate acid at different rates.
Authors
- Catherine A. Jalomo (ORCID: https://orcid.org/0000-0002-1184-7405)
- Mara L. Paterson (ORCID: https://orcid.org/0000-0003-1511-2251)
- Steven C. Zimmerman (ORCID: https://orcid.org/0000-0002-5333-3437)
- Ephraim G. Morado (ORCID: https://orcid.org/0000-0003-4436-6824)
- Amie N. Lanzendorf (ORCID: https://orcid.org/0000-0001-9125-9840)
- James F. Roberts (ORCID: https://orcid.org/0009-0007-5916-3778)
- Jazmin E. Aguilar‐Romero
Institutions
- University of Illinois Urbana-Champaign (US)
Publication Details
- Journal
- ChemistryOpen
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1002/open.202400289
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- National Institutes of Health
- Division of Chemistry