Relationship between Sperm DNA Fragmentation and Interleukin 17 in Patients with Leukocytospermia

Over the past few decades, fertility treatments have witnessed a remarkable development, inflammation in the sexual glands attached to some patients in addition to immune disorders in patients, which are among the main causes of delayed pregnancy. A hidden molecular cause of infertility is sperm DNA fragmentation which can be attributed to many cases of infertility. This study aims to correlate the relationship between sperm DNA fragmentation and interleukin 17A in patients who suffer from leukocytospermia. Samples were collected from patients with Leukocytospermia (n=30) and healthy individuals (n=18). The present study showed a significant increase in Interleukin 17A levels in Leukocytospermia patients compared with the control group (mean± Std. Error 356.5± 6.14 & 141.37± 1.32) also significant sperm DNA Fragmentation level was noticeably decreased in Leukocytospermia compare with control group (mean± Std. Error 30.85±1.17 & 79.16±3.24 Consecutive). The results show a negative correlation between the Interleukin 17A level and sperm DNA Fragmentation level in Leukocytospermia patients. The study concluded the inflammation of patients affects an increase in the percentage of abnormal sperm chromatin that was assessed using the aniline blue dye. An increase in the level of pro-inflammatory such as interleukin 17 plays a critical role in the pathogenesis and inflammation, while a negative correlation between (Interleukin 17A level and the sperm DNA Fragmentation level in Leukocytospermia patients.