Potential protective role of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) in COVID-19
The COVID-19 pandemic has prompted a quest to understand why certain individuals remain uninfected or asymptomatic despite repetitive exposure to SARS-CoV-2. Here, we focused on six exposed females residing with their symptomatic and reinfected SARS-CoV-2 PCR-positive COVID-19 partners. Peripheral blood mononuclear cell samples from couples were analysed for poly (I:C)-induced mRNA expression of type I/III interferons and interferon-stimulated genes (ISGs). Remarkably, we found a significant upregulation of the ISG interferon-inducible protein with tetrapeptide repeats 3 (IFIT3) gene exclusively in exposed uninfected or asymptomatic females, suggesting a potential role in protective immunity against symptomatic COVID-19.
Authors
- Flávia Barrosa Soares (ORCID: https://orcid.org/0000-0001-8424-0818)
- Greyce Luri Sasahara (ORCID: https://orcid.org/0000-0001-6944-7247)
- Jorge Kalil (ORCID: https://orcid.org/0000-0001-8415-4274)
- Mateus Vidigal de Castro (ORCID: https://orcid.org/0000-0002-8895-652X)
- Leonardo Moro Cariste
- Keity Souza Santos (ORCID: https://orcid.org/0000-0001-5271-4011)
- Rafael Ribeiro Almeida (ORCID: https://orcid.org/0000-0003-3984-7527)
- Moníze V. R. Silva (ORCID: https://orcid.org/0000-0002-1543-1642)
- Michel Satya Naslavsky (ORCID: https://orcid.org/0000-0002-9068-1713)
- Mayana Zatz (ORCID: https://orcid.org/0000-0003-3970-8025)
- Edécio Cunha‐Neto (ORCID: https://orcid.org/0000-0002-3699-3345)
- Vivian R. Cória
Institutions
- Universidade de São Paulo (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2024-11-27
- DOI
- https://doi.org/10.3389/fcimb.2024.1464581
- Citations
- 4
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.96
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico