Single spike mutation differentiating XBB.1 and XBB.1.5 enhances SARS-CoV-2 cell-to-cell transmission and facilitates serum-mediated enhancement
Our study demonstrates that even minor changes in the S protein can profoundly influence SARS-CoV-2 transmissibility and resistance to antibody-mediated neutralization. Understanding the molecular basis of S-mediated cell-cell fusion is crucial for anticipating the impact of emerging variants and developing next-generation therapeutic strategies. These insights provide a framework for predicting variant fitness and optimizing treatment approaches against future SARS-CoV-2 variants.
Authors
- Nicola Clementi (ORCID: https://orcid.org/0000-0002-1822-9861)
- Nicasio Mancini (ORCID: https://orcid.org/0000-0003-0637-0910)
- Sofia Sisti (ORCID: https://orcid.org/0000-0002-8006-7218)
- Roberto Burioni (ORCID: https://orcid.org/0000-0001-6760-9898)
- Elena Criscuolo (ORCID: https://orcid.org/0000-0003-0185-3147)
- Benedetta Giuliani (ORCID: https://orcid.org/0000-0003-4337-5024)
- Mattia Cavallaro (ORCID: https://orcid.org/0009-0009-4683-6202)
- Matteo Castelli (ORCID: https://orcid.org/0000-0003-0295-7941)
- Davide Ferrari (ORCID: https://orcid.org/0000-0001-7084-6800)
- Massimo Locatelli (ORCID: https://orcid.org/0000-0002-2851-712X)
Institutions
- University of Parma (IT)
- Vita-Salute San Raffaele University (IT)
- Ospedale di Circolo e Fondazione Macchi (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-27
- DOI
- https://doi.org/10.3389/fimmu.2024.1501200
- Citations
- 1
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.39