Ultrahigh-resolution 7-Tesla anatomic magnetic resonance imaging and diffusion tensor imaging of ex vivo formalin-fixed human brainstem-cerebellum complex
This novel imaging protocol successfully captured the intricate 3D architecture of the brainstem-cerebellum network. The protocol, unique in several respects (including tissue preservation and rehydration times, choice of solutions, preferred sequences, voxel sizes, and diffusion directions) aimed to balance high resolution and practical scan times. This approach provided detailed neuroanatomical imaging while avoiding impractically long scan times. The extended postmortem and fixation intervals did not compromise the diffusion imaging quality. Moreover, the combination of time efficiency and ultrahigh-resolution imaging results makes this protocol a strong candidate for optimal use in detailed neuroanatomical studies, particularly in presurgical trajectory planning.
Authors
- Ahmet Özak (ORCID: https://orcid.org/0000-0002-0688-3532)
- Muhammet Enes Gurses (ORCID: https://orcid.org/0000-0001-7141-0654)
- Giancarlo Mignucci-Jiménez (ORCID: https://orcid.org/0000-0002-1350-8829)
- Kıvanç Yangı (ORCID: https://orcid.org/0000-0003-0500-218X)
- Mark C. Preul (ORCID: https://orcid.org/0000-0002-3477-4931)
- Siyar Bahadir
- Alberto Fuentes
- Şahin Hanalıoğlu (ORCID: https://orcid.org/0000-0003-4988-4938)
- Michael T. Lawton (ORCID: https://orcid.org/0000-0002-8020-6388)
- Ethan Mathew
- Dakota Graham
- Gregory Turner (ORCID: https://orcid.org/0000-0002-9659-8291)
- Muhammed Yakup Altug
- Egemen Gok (ORCID: https://orcid.org/0009-0008-0976-5903)
Institutions
- St. Jude Children's Research Hospital (US)
- Barrow Neurological Institute (US)
- St. Joseph's Hospital and Medical Center (US)
- University of Health Science (KH)
- Akdeniz University (TR)
- Ministry of Health of the Russian Federation (RU)
- Sağlık Bilimleri Üniversitesi (TR)
- Hacettepe University (TR)
Publication Details
- Journal
- Frontiers in Human Neuroscience
- Published
- 2024-11-27
- DOI
- https://doi.org/10.3389/fnhum.2024.1484431
- Citations
- 5
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.02
Funders
- Barrow Neurological Foundation