Hypoimmunogenic CD19 CAR-NK cells derived from embryonic stem cells suppress the progression of human B-cell malignancies in xenograft animals
We offer a strategy for deriving homogeneous and hypoimmunogenic CD19 CAR-iNK cells with robust anti-tumor effects from ESCs. Our study has significant implications for developing hypoimmunogenic CD19 CAR-NK cell therapy using human ESC as an unlimited cell source.
Authors
- Qitong Weng (ORCID: https://orcid.org/0009-0003-3929-4384)
- Hui Zeng (ORCID: https://orcid.org/0000-0002-7456-6061)
- Qi Zhang (ORCID: https://orcid.org/0000-0001-8939-4111)
- Xiujuan Zheng (ORCID: https://orcid.org/0000-0002-4703-9530)
- Yanhong Liu (ORCID: https://orcid.org/0000-0002-0759-7597)
- Dehao Huang (ORCID: https://orcid.org/0009-0006-2693-9309)
- Mengyun Zhang (ORCID: https://orcid.org/0000-0003-1505-3757)
- Leqiang Zhang (ORCID: https://orcid.org/0000-0003-1439-1287)
- Chengxiang Xia (ORCID: https://orcid.org/0000-0002-7923-2802)
- Yunqing Lin (ORCID: https://orcid.org/0000-0002-6743-954X)
- Yao Wang (ORCID: https://orcid.org/0000-0003-4432-1335)
- Lijuan Liu (ORCID: https://orcid.org/0000-0001-8068-8498)
- Min Zhang (ORCID: https://orcid.org/0000-0002-4344-9815)
- Yi Chen (ORCID: https://orcid.org/0000-0002-8298-0350)
- Jinyong Wang (ORCID: https://orcid.org/0000-0001-6137-0193)
- Fangxiao Hu (ORCID: https://orcid.org/0009-0000-9376-6870)
- Yanping Zhu (ORCID: https://orcid.org/0000-0003-4524-0350)
- Tongjie Wang (ORCID: https://orcid.org/0000-0003-1207-8377)
- Hanmeng Qi
- Yiyuan Shen (ORCID: https://orcid.org/0009-0000-5954-270X)
Institutions
- Chinese Academy of Sciences (CN)
- First Affiliated Hospital of Jinan University (CN)
- Institute of Zoology (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-27
- DOI
- https://doi.org/10.3389/fimmu.2024.1504459
- Citations
- 6
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 1.44
Funders
- National Natural Science Foundation of China