Coronary Microvascular Dysfunction Is Associated With Augmented Lysosomal Signaling in Hypercholesterolemic Mice
These results suggest that CMD can develop and precede detectable cardiac functional or structural changes in the setting of hypercholesterolemia and that upregulation of transcriptional factor EB-mediated lysosomal signaling in endothelial cells plays a protective role against CMD.
Authors
- Pin‐Lan Li (ORCID: https://orcid.org/0000-0002-0797-8947)
- Yang Zhang (ORCID: https://orcid.org/0000-0002-8338-3013)
- Zhengchao Wang (ORCID: https://orcid.org/0000-0001-7439-9630)
- Yunting Wang (ORCID: https://orcid.org/0000-0001-6190-4351)
- Rui Zuo (ORCID: https://orcid.org/0000-0002-3564-1356)
- Xiang Li (ORCID: https://orcid.org/0000-0002-6865-6300)
- Wei Zhou (ORCID: https://orcid.org/0000-0002-3224-7046)
- Kiana Roudbari
- Alexandra K. Moura
- Jenny Z. Hu
Institutions
- Fujian Normal University (CN)
- Virginia Commonwealth University (US)
- Tongji Hospital (CN)
- University of Houston (US)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1161/jaha.124.037460
- Citations
- 9
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.16