Identification of Novel Proteins Mediating Causal Association Between Smoking and Essential Hypertension: A Mendelian Randomization Study
This study identified the 8 proteins that mediate causal association between smoking and essential hypertension. Interferon λ receptor agonist targeting IFNLR1 may open a new avenue for treating hypertension. Our discoveries provide new insights into protein pathogenesis of hypertension and to better guide hypertension prevention and treatment among smokers.
Authors
- Zhuoshuai Liang (ORCID: https://orcid.org/0000-0001-9370-8056)
- Huizhen Jin (ORCID: https://orcid.org/0000-0002-9399-9268)
- Yuyang Tian (ORCID: https://orcid.org/0009-0005-8300-625X)
- Zhilin Liu (ORCID: https://orcid.org/0000-0002-7495-7994)
- Ming Zhang (ORCID: https://orcid.org/0009-0009-7565-3798)
- Yawen Liu (ORCID: https://orcid.org/0000-0003-2859-4771)
- Lingfeng Pan
- Yi Cheng (ORCID: https://orcid.org/0000-0002-7352-3641)
- Jikang Shi
- Xinmeng Hu
Institutions
- Jilin University (CN)
- TUM Klinikum (DE)
- First Hospital of Jilin University (CN)
- Peking University Shenzhen Hospital (CN)
- Technical University of Munich (DE)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1161/jaha.124.036202
- Citations
- 5
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- National Natural Science Foundation of China
- People's Government of Jilin Province
- Department of Science and Technology of Jilin Province
- Basic and Applied Basic Research Foundation of Guangdong Province