Oxcarbazepine and clozapine interaction

The atypical antipsychotic clozapine is considered the primary agent for patients with treatment‐resistant schizophrenia, and is also used at times in the treatment of other treatment‐resistant psychotic disorders. Despite its efficacy, use of clozapine is often limited by the occurrence of significant adverse effects, smoking‐induced increased metabolism, and drug‐drug interactions due to co‐administered medications to treat concurrent medical and psychiatric conditions.