Combined bisoprolol and trimetazidine ameliorate arsenic trioxide -induced acute myocardial injury in rats: targeting PI3K/GSK-3β/Nrf2/HO-1 and NF-κB/iNOS signaling pathways, inflammatory mediators and apoptosis
The present research depicted that BIS and TMZ have the potential to protect the heart and provide therapeutic benefits by preventing acute heart injury induced by ATO. This is achieved by reversing the redox-sensitive pathway, reducing inflammation, and inhibiting apoptosis.
Authors
- Basel A. Abdel‐Wahab (ORCID: https://orcid.org/0000-0002-5545-6422)
- Yasmin M. Ahmed (ORCID: https://orcid.org/0000-0001-5145-8458)
- Magy R. Kozman (ORCID: https://orcid.org/0000-0002-3637-0922)
- Ehab A. M. El‐Shoura (ORCID: https://orcid.org/0000-0003-2448-7549)
- Asmaa Ramadan Abdel-Sattar
Institutions
- Misr University for Science and Technology (EG)
- Nile Valley University (SD)
- Al-Azhar University (EG)
- Al-Azhar University (ID)
- Najran University (SA)
Publication Details
- Journal
- Immunopharmacology and Immunotoxicology
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1080/08923973.2024.2435323
- Citations
- 2
- Primary Topic
- Retinoids in leukemia and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 0.47