Impeding Nucleotide‐Binding Oligomerization Domain‐Like Receptor 3 Inflammasome Ameliorates Cardiac Remodeling and Dysfunction in Obesity‐Associated Cardiomyopathy
Our study confirms that aberrant NLRP3 inflammasome activation in cardiomyocytes worsens obesity-associated cardiomyopathy and implicates inhibition of NLRP3 inflammasome as a potent therapeutic approach for obesity cardiomyopathy.
Authors
- Shi‐qiang Liu
- Tong Zhang (ORCID: https://orcid.org/0000-0003-2377-6779)
- M CHEN
- Saiyang Xie (ORCID: https://orcid.org/0000-0002-5021-6315)
- Si Chen (ORCID: https://orcid.org/0000-0002-5631-7942)
- Xiaofeng Zeng (ORCID: https://orcid.org/0000-0002-3883-2318)
- Qizhu Tang (ORCID: https://orcid.org/0000-0003-2210-3169)
- Shasha Wang (ORCID: https://orcid.org/0000-0002-4725-3158)
- Lanlan Li (ORCID: https://orcid.org/0000-0002-7068-698X)
- Yun Xing (ORCID: https://orcid.org/0000-0003-2905-0709)
- Wei Deng
- Nan Zhao (ORCID: https://orcid.org/0009-0004-1651-2921)
- Heng Zhang (ORCID: https://orcid.org/0009-0001-2785-2129)
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1161/jaha.124.035234
- Citations
- 6
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.40