Base‐Promoted [4+3] Cycloadditions of <i>N</i>‐Thioacylimines with α‐Chlorohydroxamates: Construction of 1,3,5‐Thiadiazepin‐6(7<i>H</i>)‐One Derivatives
Abstract A metal‐free base‐promoted [4+3] cycloaddition reaction of N ‐thioacyl imines in situ generated from α‐amido sulfones with α‐chlorohydroxamates is described. The reaction allows the straightforward synthesis of 1,3,5‐thiadiazepin‐6(7 H )‐one derivatives in 44~90% yields. Moreover, a gram‐scale reaction and a product transformation were conducted, which further increased the diversity of products.
Authors
- Zhao‐Lin He (ORCID: https://orcid.org/0000-0003-2661-0344)
- Y. C. Liu
- Gang Wang (ORCID: https://orcid.org/0000-0002-0358-2347)
- Yang Shao (ORCID: https://orcid.org/0000-0002-1631-9206)
Institutions
- Wuhan Institute of Technology (CN)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1002/adsc.202401193
- Primary Topic
- Synthesis and Catalytic Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00