New Cardiovascular Biomarkers in Patients with Advanced Cancer – A Prospective Study Comparing MR-proADM, MR-proANP, Copeptin, High-Sensitivity Troponin T and NT-proBNP
MR-proADM is an independent predictor of mortality in advanced stage, hospitalized cancer patients without significant CV disease or current infection. The optimal MR-proADM cut-point for mortality prediction was 0.94 nmol/L with hazards for mortality being approximately 2.5 times higher. There was a continuous increase in mortality risk with stepwise increase of MR-proADM concentrations. Elevated concentrations of MR-proADM were also associated with reduced performance status and mildly reduced left ventricular diastolic function as well as higher age and more often cancer stage IV.
Authors
- Markus S. Anker (ORCID: https://orcid.org/0000-0002-4406-8555)
- Pia Weinländer
- Jan Porthun (ORCID: https://orcid.org/0000-0002-4100-4361)
- Javed Butler (ORCID: https://orcid.org/0000-0001-7683-4720)
- Ulrich Bernd Keller (ORCID: https://orcid.org/0000-0002-8485-1958)
- Alessia Lena (ORCID: https://orcid.org/0000-0002-1550-7870)
- Ulf Landmesser (ORCID: https://orcid.org/0000-0002-0214-3203)
- Lars Bullinger (ORCID: https://orcid.org/0000-0002-5890-5510)
- Stephan von Haehling (ORCID: https://orcid.org/0000-0002-9818-042X)
- Amir Abbas Mahabadi (ORCID: https://orcid.org/0000-0003-2336-7991)
- Tienush Rassaf (ORCID: https://orcid.org/0000-0001-8001-0265)
- Sara Hadzibegovic
- Mahir Karakas (ORCID: https://orcid.org/0000-0002-5715-2959)
- Ruben Evertz (ORCID: https://orcid.org/0000-0002-5904-4652)
- Muhammad Shahzeb Khan (ORCID: https://orcid.org/0000-0002-9089-8330)
- Stefan D. Anker (ORCID: https://orcid.org/0000-0003-3331-7314)
- Matthias Totzeck (ORCID: https://orcid.org/0000-0001-5574-948X)
- Laura C. Lück
- Ursula M. Wilkenshoff
Institutions
- Joint Commission (US)
- Universität Hamburg (DE)
- Norwegian University of Science and Technology (NO)
- Max Delbrück Center (DE)
- University of Mississippi (US)
- Humboldt-Universität zu Berlin (DE)
- German Cancer Society (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Baylor Medical Center at Garland (US)
- Universitätsmedizin Göttingen (DE)
- Duke Medical Center (US)
- Berlin-Brandenburger Centrum für Regenerative Therapien (DE)
- German Centre for Cardiovascular Research (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Deutsches Herzzentrum München (DE)
- West German Heart and Vascular Center Essen (DE)
- Franklin University (US)
- University of Göttingen (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- European Journal of Heart Failure
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1002/ejhf.3497
- Citations
- 6
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 2.41
Funders
- Deutsches Zentrum für Herz-Kreislaufforschung
- Deutsche Herzstiftung