A ketogenic diet alleviates the apoptosis of granulosa cells by inhibiting the activation of cGAS-STING signaling pathway in PCOS mice
These findings, for the first time, revealed that hyperandrogenism induced ovarian dysfunction possibly through activation of the cGAS-STING pathway, which could be partially inhibited by ketone bodies produced from KD administration.
Authors
- Wenpei Bai (ORCID: https://orcid.org/0000-0002-1050-8460)
- Qiyang Yao
- Haowen Wu (ORCID: https://orcid.org/0000-0001-9410-801X)
- Jihong Kang (ORCID: https://orcid.org/0000-0002-0973-9632)
- Bining Zhao
Institutions
- Capital Medical University (CN)
- Peking University (CN)
- Beijing Shijitan Hospital (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1186/s12964-024-01939-6
- Citations
- 13
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 3.71
Funders
- National Natural Science Foundation of China