Diagnostic Significance of Mean Platelet Volume and Erythrocyte Distribution Width in Calves with Sepsis

Medical studies conducted on humans have revealed significant changes in hematological parameters dur-ing sepsis and used these changes for diagnostic and prognostic purposes. However, there are very few studies on the diagnostic and prognostic utility of hematological parameters in the field of veterinary medicine. The objective of this study was to assess whether the parameters mean platelet volume (MPV), erythrocyte distribution width standard devi-ation/coefficient of variation (RDW-SD/CV), platelet distribution width (PDW) and plateletcrit (PCT) hold diagnostic significance in identifying sepsis in calves, while also investigating the interrelationships of these parameters within these sepsis group. The study included 45 calves diagnosed with sepsis and healthy 15 calves as control group. In calves with sepsis, MPV, PCT, RDW-SD, RDW-CV and total leukocyte count were found to be significantly higher than the control group. In their analysis for the diagnosis of sepsis in calves, the sensitivity of MPV was 86.67, the specificity was 84.44, the area under the curve (AUC) was 0.91, and the cut-off point value was 5.95 fL. In addition, the AUC values for other parameters were found as PCT 0.79 (P=0.009), RDW-SD 0.68, RDW-CV 0.75 and WBC 0.80, respec-tively. In the correlation analysis between MPV and other parameters, it was determined that there was a significant relationship between PCT 0.630, PDW 0.310, WBC 0.271, RDW-SD 0.383 and RDW-CV 0.-643. In conclusion, MPV may be a useful biomarker in calves with sepsis due to its favorable diagnostic performance in the early detection of sepsis in new born calves with diarrhea. In order to determine the effects of the results in this study on sepsis very well, it is necessary to work with populations with large sample numbers in the future.