Spinal cord blood flow elevation with systemic vasopressor noradrenaline is partly mediated by vasodilation of spinal arteries due to reduced expression of alpha adrenoreceptors
These findings challenge the assumption that SCBF is solely dictated by MAP within autoregulatory limits, emphasizing the necessity of considering noradrenaline-induced vasorelaxation in the spinal arteries of TSCI patients.
Authors
- Christian Staehr (ORCID: https://orcid.org/0000-0001-5431-4409)
- Rajkumar Rajanathan (ORCID: https://orcid.org/0000-0002-5002-5244)
- Elizaveta Melnikova (ORCID: https://orcid.org/0000-0002-9033-1588)
- Vladimir V. Matchkov (ORCID: https://orcid.org/0000-0002-3303-1095)
- Mikkel Mylius Rasmussen (ORCID: https://orcid.org/0000-0002-4768-7255)
- Mathias Møller Thygesen (ORCID: https://orcid.org/0000-0002-6544-8450)
- Mads Rasmussen (ORCID: https://orcid.org/0000-0002-0416-6767)
- Seyar Entezari
- Mathias Skov (ORCID: https://orcid.org/0009-0002-4711-4729)
Institutions
- Aarhus University (DK)
- Aarhus University Hospital (DK)
Publication Details
- Journal
- The Spine Journal
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1016/j.spinee.2024.11.010
- Citations
- 2
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 0.85
Funders
- Lundbeckfonden
- H. Lundbeck A/S