Calciphylaxis in a Patient on Hemodialysis: A Case Report

Calciphylaxis is a rare but life-threatening complication of end-stage renal disease (ESRD), most often seen in patients undergoing hemodialysis. This condition is driven by calcium deposition in small blood vessels, leading to restricted blood flow, tissue ischemia, and often severe pain. While calciphylaxis typically affects areas with increased adiposity, such as the abdomen and proximal extremities, it can manifest on any skin surface, including rare sites like the genital region. Managing calciphylaxis is particularly challenging due to its rapid progression and limited treatment options. We report the case of a 53-year-old man with ESRD caused by long-standing diabetes, who developed painful necrotic lesions on the glans penis. Despite early diagnosis and treatment with sodium thiosulfate, his condition rapidly worsened. This case highlights the devastating progression of penile calciphylaxis and the complexities of managing such a rare presentation.