UBR1 Promotes Sex-Dependent ACE2 Ubiquitination in Hypertension
These data demonstrate that UBR1 is a novel E3 ubiquitin ligase targeting ACE2 in hypertension. UBR1 and Nedd4-2 appear to work synergistically to ubiquitinate ACE2. Targeting these ubiquitin ligases may represent a novel strategy to restore ACE2 compensatory activity in hypertension.
Authors
- L. Restivo (ORCID: https://orcid.org/0009-0008-2438-1529)
- Clara Berdasco
- Amy Scarborough (ORCID: https://orcid.org/0000-0002-8275-891X)
- Srinivas Sriramula (ORCID: https://orcid.org/0000-0001-9937-1589)
- Navya Lakkappa (ORCID: https://orcid.org/0000-0003-2079-5675)
- Jiaxi Xu (ORCID: https://orcid.org/0000-0002-0694-813X)
- Eric Lazartigues (ORCID: https://orcid.org/0000-0001-7290-0786)
- Franck Mauvais‐Jarvis (ORCID: https://orcid.org/0000-0002-0874-0754)
- Michelle Mendiola (ORCID: https://orcid.org/0000-0001-9348-7708)
- Uma Priya Mohan (ORCID: https://orcid.org/0000-0003-2757-0735)
- Xinping Yue (ORCID: https://orcid.org/0000-0002-4834-6612)
- Alexa Martinez (ORCID: https://orcid.org/0000-0001-9376-5368)
- Catalin M. Filipeanu (ORCID: https://orcid.org/0000-0002-7298-9327)
- Mona Elgazzaz (ORCID: https://orcid.org/0000-0002-8437-2789)
- Anna Maria Nuzzo (ORCID: https://orcid.org/0000-0001-9115-2007)
- Jessie J. Guidry (ORCID: https://orcid.org/0000-0002-5601-0430)
- Dawn E. Bowles (ORCID: https://orcid.org/0000-0002-2781-1300)
- Hisham Daoud (ORCID: https://orcid.org/0000-0002-2067-7575)
- Andreas Beyer (ORCID: https://orcid.org/0000-0001-9129-7492)
Institutions
- Suez Canal University (EG)
- Tulane University (US)
- MACOM (United States) (US)
- Duke University (US)
- Loyola University New Orleans (US)
- East Carolina University (US)
- University of New Orleans (US)
- Medical College of Wisconsin (US)
- Augusta University (US)
- Center for Neurosciences (US)
- Southeast Louisiana Veterans Health Care System (US)
- Io Therapeutics (United States) (US)
- Louisiana State University Health Sciences Center New Orleans (US)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Hypertension
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1161/hypertensionaha.124.23196
- Citations
- 5
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 1.79
Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health