UBR1 Promotes Sex-Dependent ACE2 Ubiquitination in Hypertension

These data demonstrate that UBR1 is a novel E3 ubiquitin ligase targeting ACE2 in hypertension. UBR1 and Nedd4-2 appear to work synergistically to ubiquitinate ACE2. Targeting these ubiquitin ligases may represent a novel strategy to restore ACE2 compensatory activity in hypertension.

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Publication Details

Journal
Hypertension
Published
2024-11-27
DOI
https://doi.org/10.1161/hypertensionaha.124.23196
Citations
5
Primary Topic
Hormonal Regulation and Hypertension
Type
article
Field-Weighted Citation Impact
1.79

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article

UBR1 Promotes Sex-Dependent ACE2 Ubiquitination in Hypertension

L. Restivo, Clara Berdasco, Amy Scarborough, Srinivas Sriramula et al.
5 citations
Hypertension
Hormonal Regulation and Hypertension
1.79
article

UBR1 Promotes Sex-Dependent ACE2 Ubiquitination in Hypertension

L. Restivo, Clara Berdasco, Amy Scarborough, Srinivas Sriramula, Navya Lakkappa, Jiaxi Xu, Eric Lazartigues, Franck Mauvais‐Jarvis, Michelle Mendiola, Uma Priya Mohan, Xinping Yue, Alexa Martinez, Catalin M. Filipeanu, Mona Elgazzaz, Anna Maria Nuzzo, Jessie J. Guidry, Dawn E. Bowles, Hisham Daoud, Andreas Beyer
article en
5 citations

Abstract

These data demonstrate that UBR1 is a novel E3 ubiquitin ligase targeting ACE2 in hypertension. UBR1 and Nedd4-2 appear to work synergistically to ubiquitinate ACE2. Targeting these ubiquitin ligases may represent a novel strategy to restore ACE2 compensatory activity in hypertension.

HypertensionVol. 82(1)
Suez Canal University (EG), Tulane University (US), MACOM (United States) (US), Duke University (US), Loyola University New Orleans (US), East Carolina University (US), University of New Orleans (US), Medical College of Wisconsin (US), Augusta University (US), Center for Neurosciences (US), Southeast Louisiana Veterans Health Care System (US), Io Therapeutics (United States) (US), Louisiana State University Health Sciences Center New Orleans (US), Xi'an Jiaotong University (CN)
U.S. Department of Veterans Affairs, National Institutes of Health
Good health and well-being
Openalex Percentile: Top 13%
Hormonal Regulation and Hypertension
1.79
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