Neutrophil CRACR2A Promotes Neutrophil Recruitment in Sterile Inflammation and Ischemic Stroke
Our results demonstrate that neutrophil CRACR2A promotes neutrophil recruitment to sites of sterile inflammation, such as ischemic stroke. Blocking the STIM1-CRACR2A interaction may be a novel therapeutic strategy to mitigate inflammation and consequent tissue injury.
Authors
- Yousang Gwack (ORCID: https://orcid.org/0000-0002-2821-9245)
- Anja Schweizer (ORCID: https://orcid.org/0000-0001-8787-3442)
- Jin‐Moo Lee (ORCID: https://orcid.org/0000-0002-3979-0906)
- Jaehyung Cho (ORCID: https://orcid.org/0000-0003-2404-3446)
- Babak Razani (ORCID: https://orcid.org/0000-0002-7172-9240)
- Jingu Lee (ORCID: https://orcid.org/0000-0001-6965-2339)
- Brett Balzraine
- Vasilisa Kuzmanova
- Deane F. Mosher
Institutions
- University of Wisconsin System (US)
- University of Wisconsin–Madison (US)
- University of California, Los Angeles (US)
- University of Pittsburgh (US)
- Washington University in St. Louis (US)
- University of California System (US)
- UPMC Health System (US)
- Mallinckrodt (United States) (US)
- Hope Center for Neurological Disorders (US)
- VA Pittsburgh Healthcare System (US)
- University of Pittsburgh Medical Center (US)
Publication Details
- Journal
- Circulation
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1161/circulationaha.124.070487
- Citations
- 10
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.47
Funders
- American Heart Association
- Washington University in St. Louis
- National Institutes of Health